Abstract
We investigated the efficacy of Shakuyaku-kanzo-to (TJ-68) in neuroleptic-induced hyperprolactinemia in 11 treated schizophrenic patients. The mean plasma prolactin level decreased significantly from 28.9 +/- 14.5 ng/mL at baseline to 22.0 +/- 15.2 ng/mL at 4 weeks. Potassium levels did not change significantly. Neither the exacerbation of psychosis nor other adverse effects occurred.
MeSH terms
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Antipsychotic Agents / adverse effects*
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Antipsychotic Agents / therapeutic use
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Dose-Response Relationship, Drug
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Drug Combinations
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Drugs, Chinese Herbal / therapeutic use*
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Glycyrrhiza
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Humans
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Hyperprolactinemia / chemically induced*
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Hyperprolactinemia / therapy
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Male
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Middle Aged
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Paeonia
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Prolactin / blood
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Schizophrenia / drug therapy*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antipsychotic Agents
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Drug Combinations
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Drugs, Chinese Herbal
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shakuyaku-kanzoh-toh
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Prolactin