Due to the possible adverse effects on fetus, the treatment of pregnant women with depression is a difficult problem in the field of psychiatry. Repetitive transcranial magnetic stimulation (rTMS) was used to treat three pregnant women with depression in the early pregnancy. After systemic treatments, the patient's depressive symptoms significantly relieved, and each of them smoothly provided a healthy baby. Up to now, we have not found that rTMS can be harmful to fetuses. RTMS may be a good choice for pregnant women with depression.