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Olanzapine-induced weight gain is associated with the −759C/T and −697G/C polymorphisms of the HTR2C gene

The Pharmacogenomics Journal volume 9, pages 234–241 (2009)Cite this article

Abstract

Weight gain, a serious problem associated with some antipsychotic drugs, notably olanzapine and clozapine, was suggested to be associated with −759C/T polymorphism of the 5-HT2C receptor gene. This study aimed to examine a potential association of two functional polymorphisms of the promoter region of this gene: −759C/T (rs3813929) and −697G/C (rs518147), with weight gain after 6 weeks of olanzapine monotherapy. It included 107 patients with schizophrenia; among them 36 are first-episode drug-naïve patients. Analysis was carried out by PCR–restriction fragment length polymorphism. A protective effect of −759T and −697C alleles was found: significantly less patients with −697C (3/51) and no patient with −759T (0/28) alleles experienced body mass index increase ⩾10% (P=0.0006 and 0.002, respectively). The same was true for drug-naïve patients possessing any of the variant alleles. There was a significant association of haplotypes with a ⩾10% body mass index increase (P=0.001). On the basis of the additional statistical analysis, the more important role of −697C allele was suggested.

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Acknowledgements

This work was financially supported by the Medical University of Gdansk, Poland (Grant W-32).

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Authors and Affiliations

  1. Department of Psychiatry, Medical University of Gdansk, Gdansk, Poland

    B R Godlewska & J Landowski

  2. Department of Psychiatry, Medical University of Lublin, Lublin, Poland

    L Olajossy-Hilkesberger, M Olajossy & H Marmurowska-Michałowska

  3. Department of Biology and Genetics, Medical University of Gdansk, Gdansk, Poland

    M Ciwoniuk & J Limon

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  1. B R Godlewska
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  2. L Olajossy-Hilkesberger
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Correspondence to B R Godlewska.

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Godlewska, B., Olajossy-Hilkesberger, L., Ciwoniuk, M. et al. Olanzapine-induced weight gain is associated with the −759C/T and −697G/C polymorphisms of the HTR2C gene. Pharmacogenomics J 9, 234–241 (2009). https://doi.org/10.1038/tpj.2009.18

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