Table 1

Data collection methods and clinical assessment time points

Scale 1	MINI	Psychiatric structured diagnostic interview instrument
Scale 2	HAMD-17	Self-rating scale for depressive symptoms
	CGIS	To access severity of disease
	QIDS-SR-16	Self-reported inventory for depressive symptoms
	SDS	To access functioning
	QOL	To access functioning
	MoCA	To access cognition
	WHODAS-II	To access functioning

	Scale assessments	Neuroimaging	Biomarkers in peripheral venous blood
Baseline	Scale 1, Scale 2	√	√
Week 12	Scale 2	√	√

CGIS, Clinical Global Impression Scale; HAMD-17, 17-item Hamilton Depression Rating Scale; MINI, Mini International Neuropsychiatric Interview; MoCA, Montreal Cognitive Assessment; QIDS-SR-16, Quick Inventory of Depressive Symptomatology (Self-Reported); QOL, Quality of Life; SDS, Sheehan Disability Scale; WHO-DAS II, WHO Disability Assessment Schedule.