Table 5

Areas of cortical thickness significantly reduced in patients with Alzheimer’s disease compared with amnestic mild cognitive impairment

Left hemisphere				Right hemisphere
Brain region	Peak v ertex t alairach	t	P values	Brain region	Peak vertex talairach	t	P values
Brain region	x y z	t	P values	Brain region	x y z	t	P values
Inferior temporal gyrus	−53.2 −59.2 −9.8	2.592	0.012	Isthmus-cingulate cortex	4.8 −47.4 21.8	3.735	<0.001
Isthmus-cingulate cortex	−4.7 −49.4 18.8	2.589	0.012	Lateral orbitofrontal cortex	30.9 27.0 −6.8	3.918	<0.001
Middle temporal gyrus	−51.4 −60.1 3.1	2.524	0.015	Precuneus cortex	9.8 −54.5 25.3	3.62	0.001
Insula cortex	−34.8 10.9 −4.0	2.504	0.015	Superior frontal gyrus	15.9 44.4 5.75	2.778	0.008
Inferior parietal cortex	−32.4 −76.7 19.0	2.523	0.015	Medial orbital frontal cortex	14.2 42.5 −2.4	2.749	0.008
Fusiform gyrus	−41.2 −50.7 −15.9	2.368	0.021	Middle temporal gyrus	55.5 –12.3 −20.8	2.654	0.010
Precuneus cortex	−8.7 −59.0 15.0	2.234	0.030	Insula cortex	34.8 −25.4 5.1	2.409	0.019
Pars triangularis	−30.3 28.6 7.2	2.174	0.034	Posterior-cingulate cortex	3.8 −18.5 34.2	2.29	0.026
Pericalcarine cortex	−19.3 −70.1 8.4	2.172	0.034	Parahippocampal gyrus	22.9 −22.4 −22.4	2.212	0.031
Superior parietal cortex	−24.2 −65.0 27.6	2.149	0.036	Caudal middle frontal gyrus	31.5 3.8 54.0	2.126	0.038
Lateral occipital cortex	−39.2 −69.9 2.8	2.125	0.038	Fusiform gyrus	29.3 −68.7 −8.1	2.06	0.044
Rostral anterior cingulate cortex	−6.0 35.3 −6.5	2.115	0.039	Superior parietal cortex	15.8 −73.3 45.0	2.012	0.049