Table 3

Brain regions associated with prodromal Alzheimer’s disease

RegionsSubjectsTargetsStandardsAccuracyReferences
Core regions
MTLTotal: 1077 (SR)Identify MCIFollow‐upSE: 64%, SP: 65%Lombardi et al 99
NC: 79,
Pre-AD: 50,
MCI/AD: 274
Identify amyloid-β pathologyFollow‐up, CSFAUC: 0.87Petrone et al 108
MCI: 258MCI conversionFollow‐up 3 years, PET/CSFHR:1.682 to ADPyun et al 101
HippocampusNC: 90,
MCI: 145
MCI conversionFollow‐up 1–2 yearsConversion prediction: 91.76%Zhang et al 113
NC: 213,
MCI: 216,
AD: 130
MCI conversionFollow‐up 3 yearsAUC (MRI): 0.81,
AUC (MRI+cognition): 0.85
Hett et al 114
MCI: 407Identify amyloid-β pathologyCSFAUC (radiomics analysis): 0.67,
AUC (combined model): 0.82
Park et al 109
Total: 2209 (SR)Identify MCIFollow‐upSE: 73%, SP: 71%Lombardi et al 99
NC: 121, mild AD: 145, MCI: 194MCI conversionFollow‐up ≥2 yearsAUC (texture): 0.79,
AUC (composite): 0.81,
AUC (volume): 0.74
Lee et al 97
MCI: 295MCI conversionFollow‐up 5 yearsLarger volume associated with 45% and 81% lower risk of conversion from MCI to ADTabatabaei-Jafari et al 98
NC: 305, obj-SCD: 153, MCI: 289Differences between amyloid-β±Follow‐up, PETA+ had lower volume of the presubiculum (3.4% smaller)Thomas et al 102
NC: 337, MCI: 375, AD: 98Identify amyloid-β pathologyFollow‐up, PET/CSFAUC (MCI): 0.81, AUC (NC): 0.74Ten Kate et al 107
Entorhinal cortexNC: 60,
SCD: 60,
MCI: 80
MCI conversion to ADFollow‐up ≥1 year, PET/CSFAUC: 0.70 (SE: 53%, SP: 86%)Traschütz et al 103
NC: 305,
obj-SCD: 153,
MCI: 289
Obj-SCD and MCI outcomesFollow‐up 4 years and PETObj-SCD (r=−0.126) and MCI (r=−0.261) had faster entorhinal cortex thinningThomas et al 102
Non-core regions
Lateral ventriclesTotal: 1077 (SR)Identify MCIFollow‐upSE: 57%, SP: 64%Lombardi et al 99
Posterior cortexMCI: 258MCI conversionFollow‐up 3 years, PET/CSFHR: 2.244 (1.497–3.364)Pyun et al 101
  • AD, Alzheimer’s disease; AUC, area under the receiver operating characteristic curve; CSF, cerebrospinal fluid; HR, hazard ratio; MCI, mild cognitive impairment; MTL, medial temporal lobe; NC, cognitively normal adults; obj-SCD, objectively defined subtle cognitive decline; PET, positron emission tomography; SCD, subjective cognitive decline; SE, sensitivity; SP, specificity; SR, system review.