Table 1

Causal associations between T2D and ADHD

ExposureOutcomeMethodb (SE)OR (95% CI)N_IVP value
ADHD2019T2DIVW0.262 (0.058)1.30 (1.16 to 1.46)106.49E−06
ADHD2019T2DWM0.303 (0.074)1.35 (1.17 to 1.56)103.79E−05
ADHD2019T2DMR Egger0.465 (0.275)1.59 (0.93 to 2.73)100.129
ADHD2022T2DIVW0.264 (0.154)1.30 (0.96 to 1.76)260.086
ADHD2022T2DWM0.374 (0.128)1.45 (1.13 to 1.87)263.51E−03
ADHD2022T2DMR Egger−0.262 (0.544)0.77 (0.27 to 2.23)260.634
T2DADHD2019IVW0.045 (0.014)1.05 (1.02 to 1.07)1941.06E−03
T2DADHD2019WM0.035 (0.018)1.04 (1.00 to 1.07)1940.047
T2DADHD2019MR Egger0.022 (0.045)1.02 (0.94 to 1.12)1940.635
T2DADHD2022IVW0.028 (0.008)1.03 (1.01 to 1.04)1943.65E−04
T2DADHD2022WM0.021 (0.008)1.02 (1.00 to 1.04)1940.014
T2DADHD2022MR Egger0.002 (0.026)1.00 (0.95 to 1.05)1940.952
  • ADHD, attention-deficit/hyperactivity disorder; CI, confidence interval; IVW, inverse variance weighted; MR, Mendelian randomisation; N_IV, number of instrumental variables; OR, odds ratio; SE, standard error; T2D, type 2 diabetes; WM, weighted median.