TCSA subtests: mean scores by diagnosis, and AUC scores for MMSE and TCSA for differentiating HC from MCI by education
| Items | MCI (n=46) | Dementia (n=44) | HC (n=61) | Z | P value |
| Primary screening task (median (IQR)) | |||||
| Episodic image recognition (6) | 2 (0–4) | 0 (0–0) | 5 (3–5) | 62.93 | <0.001 |
| Shult Grid (3) | 3 (2–3) | 2 (1–3) | 3 (3–3) | 29.88 | <0.001 |
| Episodic image recall (2) | 1 (0–1) | 0 (0–1) | 2 (1–2) | 36.68 | <0.001 |
| Secondary screening task (median (IQR)) | |||||
| Language (6) | 2 (0–4) | 0 (0–0) | 4 (3–5) | 67.43 | <0.001 |
| Orientation (5) | 5 (4–5) | 2 (1–4) | 5 (4–5) | 58.96 | <0.001 |
| Calculation (5) | 5 (4–5) | 5 (3–5) | 5 (5–5) | 10.85 | <0.001 |
| Short-term memory (5) | 1 (0.3–2) | 1 (0–1.8) | 2 (1–4) | 33.32 | <0.001 |
| Attention (5) | 4 (2–4) | 3 (1–3) | 5 (4–5) | 51.17 | <0.001 |
| Working memory (2) | 1 (0–1) | 1 (0–1) | 1 (0–2) | 3.11 | 0.211 |
| Naming (2) | 2 (1–2) | 2 (1–2) | 2 (2–2) | 11.08 | <0.001 |
| Group (MCI and HC, n=107) | Screening variables |
Area under curve
(95% CI) | P value | ||
| Education <12 years, n=48 | MMSE total score | 0.660 (0.38 to 0.94) | 0.202 | ||
| TCSAprimary task total score | 0.757 (0.57 to 0.94) | 0.040 | |||
| TCSAsecondary task total score | 0.637 (0.43 to 0.85) | 0.274 | |||
| Education >=12 years, n=59 | MMSE total score | 0.685 (0.46 to 0.91) | 0.109 | ||
| TCSAprimary task total score | 0.778 (0.59 to 0.96) | 0.016 | |||
| TCSAsecondary task total score | 0.759 (0.56 to 0.96) | 0.025 | |||
Task scores were calculated by Kruskal-Wallis test, statistic value: Z.
Values are means (SD) or medians (IQR); the score of each task shown in the column after the name of the test.
AUC, area under curve; HC, healthy control; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; TCSA, Thoven Cognitive Self-Assessment.