Table 2

Inflammatory proteins with significant statistical differences in clinical symptoms among melancholic, atypical and anxious depression subtypes

Time/symptomsSubtypesClinical symptomsProtein labelAveExp. group 1AveExp. group 2LogFCP valueAdjusted p valueFold changeRegulation
Baseline/appetiteDecreased versus increasedTNF-α7.7286.4171.311 0.018 0.0632.482Up
MDecreased versus increasedTNF-α8.1235.5682.556 0.038 0.1555.879Up
Baseline/painM versus ANMild to moderateTNF-α8.2406.8331.407 0.042 0.1462.651Up
AT versus ANSeverehsCRP9.6449.2430.401 0.022 0.1551.321Up
ANNone versus severehsCRP9.7259.2430.483 0.001 0.010 1.397Up
ANMild to moderate versus severehsCRP9.6409.2430.398 0.005 0.038 1.317Up
8-week follow-upM versus ATNo remissionIL-63.2504.836−1.586 0.018 0.0630.333Down
AT versus ANNo remissionIL-64.8363.0851.751 0.016 0.1093.366Up
ATNo remission versus remissionIL-64.8362.1842.651 0.001 0.006 6.283Up
ATNo remission versus remissionTNF-α8.7936.2202.573 0.011 0.038 5.953Up
12-week follow-upATNo remission versus remissionIL-64.2582.0442.214 0.022 0.0774.639Up
  • AveExp. group 1 and AveExp. group 2 represent the mean logarithmically transformed levels of the two groups involved in the comparison. In this study, the p value was adjusted by the method of Benjamini-Hochberg. Bold p values indicate <0.05.

  • AN, anxious depression subtype; AT, atypical depression subtype; hsCRP, high-sensitivity C reactive protein ; IL, interleukin; M, melancholic depression subtype; TNF-α, tumour necrosis factor-α.