Table 2

Standard assessments and detailed assessments of objective measures

Objective measuresStandard assessmentsDetailed assessments
Neurocognitive functionMATRICS Consensus Cognitive Battery (MCCB)
Information processing speedTrail Making Test Part A
Brief Assessment of Cognition in Schizophrenia: Symbol Coding (BACS-SC)
Category fluency
Verbal learningHopkins Verbal Learning Test (HVLT)
Visual learningBrief Visuospatial Memory Test-Revised (BVMT-R)
Working memoryWechsler Memory Scale Spatial span
Anthropometric measurementAnthropometric measurementHeight
Waist circumference
Body mass index
Upper arm circumference
Blood pressure
PlasmaMetabolic and immune markersBlood pathology analysis
Full blood count
Urea, triglycerides, cholesterol, apolipoprotein
Thyroid function
Fasting blood glucose, insulin, β-hydroxybutyric acid
More extensive molecular biologic marker screeningDNA, RNA, neuroimmune cytokines, protein, exosomes, etc
FaecesIntestinal floraAbundance of microbial compositions, Alpha-diversity
EEGResting-state EEGDelta, Theta, Alpha, Beta and Gamma bands
Brain structure and functionBrain structureCortical thickness, surface area, cortical and subcortical volume and mean curvature
Brain functionMetrics of local brain activity: ALFF, ReHo, DC, VMHC, etc
Functional connectivity: static and dynamic FC
Global and Network Metrics: small world, global efficiency, rich-club, clustering coefficient, shortest path length, betweenness-centrality local efficiency, etc
  • ALFF, amplitude of low-frequency fluctuation; DC, degree centrality; EEG, electroencephalography; FC, functional connectivity; MATRICS, Measurement and Treatment Research to Improve Cognition in Schizophrenia; ReHo, regional homogeneity; VMHC, voxel-mirrored homotopic connectivity.