Summary of FDA-approved medications for bipolar depression
Pharmacological agent | Year approved | Common adverse effects | Effectiveness |
Olanzapine + fluoxetine | 2003 |
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Quetiapine | 2008 |
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Lurasidone | 2013 |
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Cariprazine | 2019 |
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Lumateperone | 2021 |
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CI, confidence interval; FDA, Food and Drug Administration; MADRS, Montgomery-Asberg Depression Rating Scale; NNT, needed to treat; OFC, olanzapine plus fluoxetine; OR, odds ratio.