PT  - JOURNAL ARTICLE
AU  - Antonino Petralia
AU  - Emanuele Bisso
AU  - Ilaria Concas
AU  - Antonino Maglitto
AU  - Nunzio Bucolo
AU  - Salvatore Alaimo
AU  - Andrea Di Cataldo
AU  - Maria Salvina Signorelli
AU  - Alfredo Pulvirenti
AU  - Eugenio Aguglia
TI  - Psychopathological outcomes and defence mechanisms in clinically healed adults with a paediatric cancer history: an exploratory study
AID  - 10.1136/gpsych-2020-100307
DP  - 2021 Jul 01
TA  - General Psychiatry
PG  - e100307
VI  - 34
IP  - 4
4099  - http://gpsych.bmj.com/content/34/4/e100307.short
4100  - http://gpsych.bmj.com/content/34/4/e100307.full
SO  - Gen Psych2021 Jul 01; 34
AB  - Background The incidence of paediatric cancers has increased in recent years; however, with advances in the treatment of paediatric cancer, almost 80% of children and adolescents who receive a diagnosis of cancer become long-term survivors. Given the high stress levels associated with cancer, it becomes important to ascertain the risk and likelihood of psychiatric disorders in adult paediatric cancer survivors.Aims This study aims to investigate the relationship between defence styles and predisposition to psychiatric diseases in adults with a history of paediatric cancer.Methods We performed an explorative study on a sample of 66 clinically healed adults with a history of paediatric cancer (survivors) during follow-up visits at the University Hospital ‘Policlinico G Rodolico’ of Catania (Italy) and 98 healthy controls among medicine students. We administered the Defence Mechanism Inventory (DMI) to assess defence styles. The Symptom Checklist-90-Revised (SCL-90-R) and the Davidson Trauma Scale (DTS) were administered to assess psychopathological indices. We conducted comprehensive statistical analysis based on correlation analysis and mediation analysis to investigate the relationship between defence styles and psychopathological outcomes in survivors compared with controls.Results The survivors obtained statistically significant lower values in TAO, PRO and TAS defence styles and a higher value in REV. Both groups showed non-pathlogical mean scores in DTS and SCL-90-R (with an exception of the obsessive-compulsive subscale), with lower mean values among survivors. The results of mediation analysis showed that TAS had mediation effects on interpersonal sensitivity, anxiety, PSDI, GSI and avoidance, while TAO had mediation effects on DTS total score and intrusivity. Thus, for these psychopathological indices, the effect of the oncological pathology was indirect and mediated by TAO or TAS. Our analysis exlcluded mediation effects between the remaining variables and defence styles.Conclusion Integrating data from mediation and correlation analysis, we found how the decreasing of TAS utilization in survivors as the consequence of cancer history, has decreased interpersonal sensitivity, anxiety and GSI score in these subjects compared with controls. Similary, the decrease of TAO utilization played a role in lower values of DTS total score and intrusivity subscale. Unexpectedly, our analysis excluded relationships between cancer history, other defence styles and psycopathological scores as we initially assumed.All data relevant to the study are included in the article or uploaded as supplemental information. All data have been obtained from the authors of this manuscript and are in the possession of the corresponding author.