TY - JOUR T1 - Psychosis and Dandy-Walker syndrome: a case report and review of the literature JF - General Psychiatry JO - Gen Psych DO - 10.1136/gpsych-2020-100254 VL - 34 IS - 2 SP - e100254 AU - Alejandro Porras Segovia AU - Margarita Guerrero-Jiménez AU - Carmen Maura Carrillo de Albornoz Calahorro AU - Luis Gutierrez-Rojas Y1 - 2021/04/01 UR - http://gpsych.bmj.com/content/34/2/e100254.abstract N2 - Dandy-Walker syndrome (DWS) is a group of brain malformations which sometimes present with psychotic symptoms. We present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis. A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions, auditory hallucinations and violent behaviour. The MRI performed showed the typical alterations of Dandy-Walker variant: vermian hypoplasia and cystic dilatation of the fourth ventricle. He also suffered from mild intellectual disability. After being treated with olanzapine 10 mg/d for a month, his psychotic symptoms greatly improved and he was discharged. In conclusion, DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal, thalamic and cerebellar areas. The association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia. ER -