RT Journal Article
SR Electronic
T1 Psychosis and Dandy-Walker syndrome: a case report and review of the literature
JF General Psychiatry
JO Gen Psych
FD BMJ Publishing Group Ltd
SP e100254
DO 10.1136/gpsych-2020-100254
VO 34
IS 2
A1 Alejandro Porras Segovia
A1 Margarita Guerrero-Jiménez
A1 Carmen Maura Carrillo de Albornoz Calahorro
A1 Luis Gutierrez-Rojas
YR 2021
UL http://gpsych.bmj.com/content/34/2/e100254.abstract
AB Dandy-Walker syndrome (DWS) is a group of brain malformations which sometimes present with psychotic symptoms. We present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis. A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions, auditory hallucinations and violent behaviour. The MRI performed showed the typical alterations of Dandy-Walker variant: vermian hypoplasia and cystic dilatation of the fourth ventricle. He also suffered from mild intellectual disability. After being treated with olanzapine 10 mg/d for a month, his psychotic symptoms greatly improved and he was discharged. In conclusion, DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal, thalamic and cerebellar areas. The association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia.