TY - JOUR T1 - Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being JF - General Psychiatry JO - Gen Psych DO - 10.1136/gpsych-2022-100877 VL - 35 IS - 5 SP - e100877 AU - Lei Cai AU - Yonglin Liu AU - Lin He Y1 - 2022/10/01 UR - http://gpsych.bmj.com/content/35/5/e100877.abstract N2 - Background High blood pressure is a leading cardiovascular disease risk factor and considered to be associated with psychological factors. However, the causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being are not clear.Aims The current study explored the genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being.Methods Mendelian randomisation (MR) analyses were performed using the generalised summary-data-based MR analysis method with eight large-scale genome-wide association study datasets for hypertension, systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure, anxiety, depressive symptoms, neuroticism and subjective well-being.Results A causal effect of DBP on neuroticism was found, and 1074 independent instrumental single nucleotide polymorphisms were identified by the incorporated Heterogeneity in Dependent Instruments-outlier test among the bidirectional causal relationship between blood pressure and the four psychological states.Conclusions DBP has a causal effect on neuroticism. Appropriate management of blood pressure may reduce neuroticism, neuroticism-inducing mood disorders and cardiovascular diseases.Data are available upon reasonable request. ER -