RT Journal Article SR Electronic T1 A cohort study of adolescents with depression in China: tracking multidimensional outcomes and early biomarkers for intervention JF General Psychiatry JO Gen Psych FD BMJ Publishing Group Ltd SP e100782 DO 10.1136/gpsych-2022-100782 VO 35 IS 4 A1 Xiaofei Zhang A1 Yanling Zhou A1 Jiaqi Sun A1 Ruilan Yang A1 Jianshan Chen A1 Xiaofang Cheng A1 Zezhi Li A1 Xinlei Chen A1 Chanjuan Yang A1 Xinhong Zhu A1 Liping Cao YR 2022 UL http://gpsych.bmj.com/content/35/4/e100782.abstract AB Background Depression in adolescents is recognised as a global public health concern, but little is known about the trajectory of its clinical symptoms and pathogenesis. Understanding the nature of adolescents with depression and identifying early biomarkers can facilitate personalised intervention and reduce disease burden.Aims To track multidimensional outcomes of adolescents with depression and develop objective biomarkers for diagnosis, as well as response to treatment, prognosis and guidance for early identification and intervention.Methods This is a multidimensional cohort study on the Symptomatic trajectory and Biomarkers of Early Adolescent Depression (sBEAD). We planned to recruit more than 1000 adolescents with depression and 300 healthy controls within 5 years. Multidimensional clinical presentations and objective indicators are collected at baseline, weeks 4, 8, 12 and 24, and years 1, 2, 3, 4 and 5.Conclusions To the best of our knowledge, this is the first longitudinal cohort study that examines multidimensional clinical manifestations and multilevel objective markers in Chinese adolescents with depression. This study aims at providing early individualised interventions for young, depressed patients to reduce the burden of disease.Trial registration number Chinese Clinical Trial Registry ID ChiCTR2100049066.There are no data in this work.