PT  - JOURNAL ARTICLE
AU  - Xiaofei Zhang
AU  - Yanling Zhou
AU  - Jiaqi Sun
AU  - Ruilan Yang
AU  - Jianshan Chen
AU  - Xiaofang Cheng
AU  - Zezhi Li
AU  - Xinlei Chen
AU  - Chanjuan Yang
AU  - Xinhong Zhu
AU  - Liping Cao
TI  - A cohort study of adolescents with depression in China: tracking multidimensional outcomes and early biomarkers for intervention
AID  - 10.1136/gpsych-2022-100782
DP  - 2022 Aug 01
TA  - General Psychiatry
PG  - e100782
VI  - 35
IP  - 4
4099  - http://gpsych.bmj.com/content/35/4/e100782.short
4100  - http://gpsych.bmj.com/content/35/4/e100782.full
SO  - Gen Psych2022 Aug 01; 35
AB  - Background Depression in adolescents is recognised as a global public health concern, but little is known about the trajectory of its clinical symptoms and pathogenesis. Understanding the nature of adolescents with depression and identifying early biomarkers can facilitate personalised intervention and reduce disease burden.Aims To track multidimensional outcomes of adolescents with depression and develop objective biomarkers for diagnosis, as well as response to treatment, prognosis and guidance for early identification and intervention.Methods This is a multidimensional cohort study on the Symptomatic trajectory and Biomarkers of Early Adolescent Depression (sBEAD). We planned to recruit more than 1000 adolescents with depression and 300 healthy controls within 5 years. Multidimensional clinical presentations and objective indicators are collected at baseline, weeks 4, 8, 12 and 24, and years 1, 2, 3, 4 and 5.Conclusions To the best of our knowledge, this is the first longitudinal cohort study that examines multidimensional clinical manifestations and multilevel objective markers in Chinese adolescents with depression. This study aims at providing early individualised interventions for young, depressed patients to reduce the burden of disease.Trial registration number Chinese Clinical Trial Registry ID ChiCTR2100049066.There are no data in this work.