RT Journal Article
SR Electronic
T1 Inconsistency between overall and subgroup analyses
JF General Psychiatry
JO Gen Psych
FD BMJ Publishing Group Ltd
SP e100732
DO 10.1136/gpsych-2021-100732
VO 35
IS 3
A1 Hongyue Wang
A1 Bokai Wang
A1 Xin M Tu
A1 Changyong Feng
YR 2022
UL http://gpsych.bmj.com/content/35/3/e100732.abstract
AB Suppose we have a sample of subjects in two treatment groups. To study the difference of the treatment effects, we can analyse the data using all subjects (overall analysis). We may also divide the subjects into several subgroups based on some covariates of interest (eg, gender), and study the treatment effects within each subgroup. The results of these two analyses may be different or even in opposite directions. In this paper, we give a general sufficient condition of consistency between the overall and subgroup analyses.