Main findings
The results of our study showed that in a low- to middle-income population in Pakistan, a higher frequency and intensity of hassles during the third trimester of pregnancy, as well as a higher intensity ratio of hassles to uplifts, were linked to elevated levels of postpartum symptoms of anxiety and depression. Conversely, a higher intensity of uplifts during the late stage of pregnancy was related to a decrease in symptoms of anxiety and depression. Additionally, we observed that the inverse association between uplifts frequency and postpartum anxiety and depressive symptoms was stronger among participants in the intervention arm. In other words, participation in the intervention had beneficial effects on the outcomes, that is, the intervention suppressed the positive association between depressive symptoms and hassles frequency and reinforced the negative association between depressive symptoms and hassles frequency.
Our findings demonstrated that both frequent and intense hassles during pregnancy were associated with elevated symptoms of anxiety and depression at 6 weeks post partum. Investigating the influence of hassles as a stressor during a woman’s life has been a topic of increasing interest over the last decade. A prospective cohort study conducted in the USA on health behaviours and pregnancy indicated that stress intensity during pregnancy (measured using the Prenatal Psychosocial Profile Stressor Scale11) was a key predictor of postpartum depression.19 Another study conducted in India using the PES-Brief demonstrated that women experiencing psychosocial stressors during pregnancy showed elevated hassles frequency, as well as increased intensity and frequency ratio of hassles to uplifts.20
Although negative stressors during pregnancy have been extensively investigated in relation to postpartum mental health, the role of positive stressors has been less explored. Among the studies based on the PES and PES-Brief to date, we found only a single study conducted in Japan that examined the relationship between uplifts and postpartum depression. That study reported that non-depressed postpartum women exhibited significantly higher uplifts intensity during pregnancy than depressed postpartum women.21
Most studies focusing on positive experiences during pregnancy have examined particular types of positive experiences, such as tangible or emotional support from partners,22 rather than comprehensively measuring pregnancy-specific positive experiences. In our study, uplifts, or positive stressors, were measured through multiple items, including social support (eg, positive comments from others about pregnancy, discussions with spouse about childbirth issues), positive emotions (eg, thinking about the baby’s appearance or nursery arrangements) and receiving appropriate care (eg, antenatal care). Positive stressors during pregnancy could mitigate the risk of negative postpartum mental health outcomes.
Our study further illuminated the interaction between a culturally adapted CBT-based intervention and stressors during pregnancy in relation to postpartum mental health symptoms. The effectiveness of CBT in treating postpartum depression and anxiety has been well established.23 24 According to the literature, tolerance towards uncertainty and the development of positive expectations can be enhanced by CBT,23 which were also factors mirrored in the PES-Brief used in this study (eg, negative emotions about being unwell and out of shape (hassles) and positive emotions arising from discussions of baby looks and names (uplifts)).25 26 During our intervention, participants were encouraged to identify their fears and concerns regarding pregnancy, labour and bonding with their babies, along with any unhelpful thoughts and behaviours associated with them.17 Pictorial illustrations were used to help them understand the likely consequences of such thoughts and behaviours for their own and their babies’ well-being and to encourage them to practise thinking and acting healthy.17 This was achieved by maintaining and monitoring mood charts and setting simple goals in collaboration with participants to engage them in healthy activities.17 Furthermore, their problem-solving skills were strengthened by encouraging them to focus on concerns or problems that can be changed or influenced, and to make action plans to address them. Such strategies most likely enhanced the pregnant women’s abilities to address pregnancy-associated hassles and concentrate on uplifts, as reflected in the interaction we observed between the frequency and intensity of these stressors and depression and anxiety. Social support during pregnancy protects against depression.27 Our intervention aimed to promote social support by encouraging significant involvement of family members during delivery and while planning for the baby’s arrival. Building social support networks may have helped participants feel supported and better prepared for childbirth, which could have contributed to the moderating effect of the intervention on their mental health.
Our study revealed that pregnancy experiences in the third trimester, but not in early gestation, were significantly associated with mental health outcomes during the postpartum period. The intervention session delivered at the later stage of pregnancy was aimed at promoting awareness of postpartum challenges (such as baby blues, postpartum depression and breastfeeding) and strategies for staying well. The psychoeducational component of the intervention likely contributed to the mitigation of postpartum mental health consequences. These findings have important implications for clinical practice.
The present study can be considered a pioneer in its approach to analysing how experiences in pregnancy are related to mental health outcomes, with respect to both early gestation to mid-gestation (≤22 weeks) versus late pregnancy (ie, the third trimester). Compared with previous studies that focused on one or a few specific events, the strength of this study is its focus on both negative (hassles) and positive (uplifts) stressors in relation to postnatal anxiety and depressive symptoms. This study used an instrument validated in Pakistan, the PES-Brief, to measure stressors during pregnancy with high internal consistency.28 This study underscores the efficacy of CBT-based interventions in enhancing the capacity of uplifts and mitigating the adverse impact of hassles on mental health outcomes.