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Biological mechanism study of meditation and its application in mental disorders
  1. Hui Shen1,
  2. Meijuan Chen1 and
  3. Donghong Cui1,2
  1. 1 Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. 2 Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China
  1. Correspondence to Dr Donghong Cui; manyucc{at}


In recent years, research on meditation as an important alternative therapy has developed rapidly and been widely applied in clinical medicine. Mechanism studies of meditation have also developed progressively, showing that meditation has great impact on brain structure and function, and epigenetic and telomere regulation. In line with this, the application of meditation has gradually been expanded to mental illness, most often applied for major depressive disorders and substance-related and addictive disorders. The focus of this paper is to illustrate the biological mechanisms of meditation and its application in mental disorders.

  • brain
  • depressive disorder, major
  • schizophrenia

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  • Contributors HS wrote the paper; MJC and DHC read and edited the manuscript.

  • Funding This study was funded by the following fundings:Shanghai Jiao Tong University Medical and Engineering Joint Grant (YG2016ZD06), Shanghai Jiao Tong University Joint Art and Science Funding (14JCRZ05), National Natural Science Foundation of China (81671336), National Key R&D Program of China (2017YFC0909200)

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement The data that support the findings of this study are available from the corresponding authors on reasonable request.

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