You are here

Article Text

Article menu

Download PDFPDF

Original research
Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI
  1. Yuzhu Mu1,
  2. Yumei Li2,
  3. Qi Zhang3,
  4. Zhongxiang Ding4,
  5. Mei Wang4,
  6. Xingguang Luo5,
  7. Xiaoyun Guo6 and
  8. Maosheng Xu3
  1. 1 Department of Ultrasound, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China
  2. 2 Department of Radiology, Zhejiang Provincial People's Hospital, Hospital of Hangzhou Medical College, Hangzhou, China
  3. 3 Department of Radiology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China
  4. 4 Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China
  5. 5 Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
  6. 6 Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  1. Correspondence to Dr Xiaoyun Guo; xiaoyunguo{at}163.com; Dr Maosheng Xu; xums166{at}zcmu.edu.cn

Abstract

Background The prevalence of Alzheimer’s disease (AD) comorbid with depression is common. However, the mechanisms of AD with depression remain unclear.

Aims To investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging (rs-fMRI).

Methods 154 patients with AD who met the inclusion criteria were recruited from the Zhejiang Provincial People’s Hospital from October 2014 to October 2016. According to whether the core symptoms of depression were present, patients were divided into two groups, 22 patients with AD with depression (AD-D) and 52 patients with AD without depression (AD-nD). The amplitude of low frequency fluctuations (ALFF) was compared between two groups by performing independent-samples t-test.

Results Compared with the AD-D group, increased ALFF values in the bilateral superior frontal gyrus, left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD group. The brain activity in the AD-nD group in the bilateral superior frontal gyrus, left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D group.

Conclusions Resting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms.

  • resting-state functional magnetic resonance imaging
  • Alzheimer’s disease
  • depression
  • amplitude of low frequency fluctuations
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/gpsych-2019-100147

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors YM wrote the article. QZ did the data analysis. MX and YL designed the experiment, ZD, MW, XL and XG reviewed and revised the article.

    • Funding This study was funded by Science and Technology Department of Zhejiang Province (2014C33126), Public Welfare Technology Research and Social Development Projects (2014-). This study is also funded by the National Natural Science Foundation of China (81201057), Shanghai Municipal Health Bureau Project (20124109), Chinese Medical Association, Psychiatry – Servier Youth Research Fund, Shanghai Mental Health Center international cooperation project (2013-) and Shanghai Municipal Center for Mental Health Clinical Research Program. This study is funded by Key Research Project of Zhejiang TCM Science and Technology Plan of China (2018ZZ010).

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data availability statement No data are available.