Article Text
Abstract
The clinical manifestation of frontal-variant Alzheimer’s disease (fvAD) is not typical, and it is difficult yet necessary to differentiate fvAD from frontal-variant frontal temporal dementia (fvFTD). We describe a patient with early-onset Alzheimer’s disease (AD) who presented with an fvFTD-like syndrome and apolipoprotein E ɛ3/ ɛ4 genotype. A brain amyloid imaging procedure, 11C-Pittsburgh compound B positron emission tomography (PET), supported the final diagnosis of AD. Our present case highlights the clinical variability that characterises early-onset AD. A multimodal approach is crucial when assessing rare forms of dementia.
- geriatric psychiatry
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Footnotes
HC and SN are joint first authors.
HC and SN contributed equally.
Deceased 6
Contributors SN provided the case report part. HC finished the writing of the manuscript. WL performed the literature search and LS provided critical revision for the manuscript. SN, HC, WL, XL, LS and SX contributed to and approved the final manuscript.
Funding This study was supported by a grant of Clinical Research Center Project of Shanghai Mental Health Center (CRC2017ZD02), Natural Science Foundation of China (81301139) and Western medical guidance project of Shanghai science and Technology Commission (17411970100).
Competing interests None declared.
Patient consent for publication Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.