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Role of biological rhythm dysfunction in the development and management of bipolar disorders: a review
  1. Yiming Chen1,
  2. Wu Hong1 and
  3. Yiru Fang1,2,3
  1. 1Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. 2Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China
  3. 3CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, China
  1. Correspondence to Dr Yiru Fang, Clinical Research Center & Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Key Laboratory of Psychotic Disorders, 600 South Wan Ping Road, Shanghai 200030, CHINA; yirufang{at}aliyun.com

Abstract

Disturbance of biological rhythms contributes to the onset of bipolar disorders and is an important clinical feature of the condition. To further explore the role of biological rhythms in bipolar disorders, 95 English articles published between 1968 and 2019 were retrieved from the PubMed database and analysed. We herein review the outcomes of studies on biological rhythm disturbance in bipolar disorders, including the epidemiology, aetiology, clinical features (eg, sleep, feeding and eating disorders) and treatment of the condition evaluated by patients’ self-report and biological indicators such as melatonin. Our report supports the characterisation of biological rhythm disturbance as a significant clinical feature affecting the onset and development of bipolar disorders and reviews classical and novel treatments, such as chronotherapy, that can be applied in the clinical practice. Our analysis indicates that a more comprehensive study of the pathophysiology, clinical phenomenology and treatment of biological rhythm disturbance is required.

  • bipolar disorders
  • sleep
  • feeding and eating disorders
  • melatonin
  • chronotherapy
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Footnotes

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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