How about regulating microbiota on anxiety symptoms?

On 20 May 2019, the Newsweek reported ‘Eating the right food to boost gut bacteria could ease symptoms of anxiety’ which highly praised the new systematic review published in General Psychiatry issue 2, 2019, about gut bacteria related with anxiety.1 Accumulating basic studies have indicated that gut microbiota (GM) can regulate brain function through the gut–brain axis, and dysbiosis of intestinal microbiota is closely related to anxiety. Clinical studies also indicated that in addition to the use of psychiatric drugs, we also should consider RIF to alleviate anxiety symptoms, especially for patients who are not suitable for the applications of psychiatric drugs. However, there is no specific evidence to support the efficacy of the treatment of anxiety symptoms by RIF.

Dr Chen and her colleagues conducted a systematic review of 3334 articles about the effects of regulating microbiota on anxiety symptoms and found that more than half of the studies included showed it was positive to treat anxiety symptoms by RIF.2 There were two kinds of interventions (probiotic and non-probiotic interventions) to regulate intestinal microbiota, highlighted by that the non-probiotic (mainly prebiotics) interventions were more effective than the probiotic interventions. The probiotics and non-probiotics together might have a better effect on treating mood disorders like anxiety. Furthermore, the newly published studies on probiotics treating mental disorders tend to apply something else such as vitamin D or selenium in addition to using probiotic alone, which are consistent with the finding of this systematic review and suggest that mental disorders could be treated by regulating GM and the ways to RIF are diverse. Therefore, more basic studies and relevant clinical intervention studies should be carried out to explore the mechanism and relationship between the intestinal flora adjustment and improvement of anxiety.

The new craving measurement for addiction patients

The indicator of addiction severity in clinical studies, for a long time, relies on experienced craving report for drug-related cues. This condition ranges from both addictive assessments and diagnosis to the estimation of clinical intervention. However, self-report of craving is susceptible to the influences of social desirability and self-masking in many situations. This necessitates the development of an objective measurement that can detect one’s real craving, which is independent of these obscuring factors.

The article by Dr Yuan’s team entitled ‘Assessing the severity of methamphetamine use disorder beyond the subjective craving report: the role of an attention bias test’ shows that the attention bias test represents a more reliable indicator for the addictive severity in methamphetamine (MA) dependents.3 The authors observed that MA dependents, irrespective of high or low craving reports, showed similar attention bias to drug-related photographs by using correlation analyses. Moreover, attention bias instead of craving rating was significantly correlated with each of the three clinical indexes of addictive severity.

This study provides evidence that attention bias serves as a more objective measure for addictive severity compared with the traditional craving report in addiction research.

The views about gaming disorder

Gaming is an important form of entertainment and it can bring us a moment of pleasure. However, excessive gaming may cause serious consequences for players. Gaming disorder has become a significant issue in mental healthcare. Dr Liu and his team summarise the studies about gaming disorder and give us a detail introduction of the definition, epidemiology, aetiology, diagnosis, treatment and prevention of gaming disorder.4 Substantial evidence suggested that gaming disorder was an addiction-based mental disorder. In the review, the debates and future research directions on gaming disorder are also involved.

In this issue, Dr Zhao points out that the occurrence and development of gaming disorder are closely related to individual, psychological, family and social factors and they can affect individuals’ physical, psychological, family and social functions.5 More importantly, the author concludes thatcomprehensive strategies including medical, psychological, family and social interventions could be adopted to prevent and reduce the harm of gaming disorder.

With the development of society, mental health has increasingly become an integrated part in people’s lives; thus, it is an important work to explore more efficient methods for the diagnosis, treatment and prevention of mental illness through clinical practice and basic research. The forum in issue 2 was very popular which focused on the development of psychiatry in China in 10 years. In that forum, Dr Shi gave us a comprehensive understanding of psychiatry by describing the current development of psychiatry and comparing the changes of today’s mental health with the past.6 He also shared the possible scene of visiting a psychiatrist after 10 years. This forum brings us a new perspective to better understand the development of psychiatry.