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Abstract
Bipolar disorder is associated with high rates of general medical conditions, but few cases of overlap between bipolar disorder and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) have been reported in the current literature. The following is a case of a 29-year-old patient with a previous major depressive episode comorbid with CLIPPERS. Following glucocorticosteroid therapy, the patient switched to mania-like presentation and was diagnosed with bipolar disorder due to another medical condition. So it is strongly suggested that high-dose corticosteroid pulse therapy could easily induce psychiatric disturbances for patients with previous psychiatric symptoms, and there may be potential links between bipolar disorder and CLIPPERS in the area of inflammation.
- bipolar disorder
- CLIPPERS
- comorbidity
- inflammation
- glucocorticosteroid
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Footnotes
Contributors XL finished the writing of the manuscript. YW provided critical revision for the manuscript. Both authors contributed to and approved the final manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent Obtained
Ethics approval Ethics committee approval was not necessary as the case fell within the standard of medical care.
Provenance and peer review Not commissioned; externally peer reviewed.