Table 3

Areas of cortical thickness significantly reduced in patients with Alzheimer’s disease compared with normal controls

Left hemisphere				Right hemisphere
Brain region	Peak vertex talairach	t	P values	Brain region	Peak vertex talairach	t	P values
Brain region	x y z	t	P values	Brain region	x y z	t	P values
Pericalcarine cortex	−15.3 −76.4 11.1	4.078	<0.001	Inferior parietal cortex	44.9 −56.2 28.8	3.799	<0.001
Inferior parietal cortex	−41.6 −73.9 17.7	3.355	0.001	Parahippocampal gyrus	17.9 −36.9 −9.3	3.532	0.001
Inferior temporal gyrus	−54.8 −28.4 −29.5	3.338	0.002	Inferior temporal gyrus	49.7 −57.8 −8.7	3.259	0.002
Cuneus cortex	−6.3 −71.6 16.3	3.234	0.002	Pericalcarine cortex	16.1 −78.8 8.0	3.026	0.004
Precuneus cortex	−12.9 −54.7 30.9	2.921	0.005	Lingual gyrus	13.6 −50.4 −4.2	2.916	0.005
Posterior-cingulate cortex	−6.3 −22.2 40.2	2.863	0.006	Precuneus cortex	14.7 −46.8 52.0	2.832	0.006
Lateral occipital cortex	−41.8 −79.3 −2.7	2.777	0.008	Lateral occipital cortex	46.7 −76.6 3.0	2.796	0.007
Postcentral gyrus	−30.1 −47.1 39.9	2.706	0.009	Superior frontal gyrus	23.1 2.2 47.2	2.78	0.007
Insula cortex	−34.6 −19.5 9.8	2.708	0.009	Precentral gyrus	56.6 6.6 25.0	2.765	0.008
Parahippocampal gyrus	−22.8 −33.7 −17.9	2.693	0.009	Fusiform gyrus	28.7 −62.3 −13.5	2.664	0.010
Entorhinal cortex	−23.1 −11.1 −32.7	2.728	0.009	Insula cortex	34.1 2.3 8.3	2.652	0.010
Isthmus-cingulate cortex	−5.4 −45.8 30.4	2.706	0.009	Isthmus-cingulate cortex	16.3 −49.3 4.0	2.622	0.011
Lateral orbitofrontal cortex	−27.7 29.0 −0.5	2.621	0.011	Middle temporal gyrus	59.9 −26.4 −17.2	2.617	0.011
Fusiform gyrus	−28.1 −57.6 −15.6	2.607	0.012	Entorhinal cortex	21.3 −9.3 −29.3	2.513	0.015
Superior parietal cortex	−47.7 −45.5 13.2	2.533	0.014	Cuneus cortex	5.7 −88.0 12.1	2.429	0.018
Middle temporal gyrus	−57.8 −23.1 −18.9	2.551	0.014	Postcentral gyrus	62.1 −14.6 24.0	2.408	0.019
Pars triangularis	−31.3 27.2 8.5	2.496	0.016	Medial orbital frontal cortex	6.7 26.0 −17.2	2.404	0.020
Precentral gyrus	−46.5 1.6 28.6	2.396	0.020	Supramarginal gyrus	45.1 26.9 20.6	2.261	0.028
Paracentral lobule	−15.3 −25.0 44.7	2.400	0.020	Caudal middle frontal gyrus	33.1 7.8 32.0	2.198	0.032
Caudal middle frontal gyrus	−33.0 6.6 29.1	2.330	0.024
lingual gyrus	−12.6 −71 −2.9	2.126	0.038